Accelerated Intermittent Theta Burst Stimulation (iTBS) Decreased Cigarette Cue Attentional Bias (AB) in People With Comorbid Opioid Use Disorder (OUD) and Tobacco Use Disorder (TUD). A Pilot Study

Published: 15 September 2025| Version 4 | DOI: 10.17632/kvrvcdw87t.4
Contributor:
Gopalkumar Rakesh

Description

This dataset encompasses examining the effects of the impact of accelerated intermittent theta burst stimulation (iTBS) versus sham iTBS (comprising four sessions in a day, 1800 pulses/session, delivered in an accelerated manner, at intervals of 50 minutes) on tobacco/opioid cravings and cue attentional bias (AB) for opioids/cigarettes in people with tobacco use disorder (TUD) and opioid use disorder (OUD). This is a pilot study, participants with both TUD and OUD were randomized to receive iTBS (n=8) or sham iTBS (n=7). Study Procedures. After completing a phone screen to determine eligibility, participants were scheduled for Day 1 procedures, which consisted of informed consent, collection of demographic details, measuring carbon monoxide (CO) using a Smokerlyzer Breath CO Monitor (Bedfont Scientific Ltd., Rochester, England), measuring blood alcohol level (BAL) using a Breathalyzer, administering Fagerstrom Test for Nicotine Dependence (FTND), an attentional bias screen (AB Screen) and structural MRI of the brain. All eligible study participants were randomized and scheduled to receive iTBS or sham iTBS a week from Day 1 (Day 2). On day 2, participants received four sessions of iTBS or sham iTBS at intervals of 50 minutes between sessions. The following assessments were administered in the indicated order at 3-time points (baseline, after the 1st session of iTBS/sham iTBS, and after the 4th session of iTBS/sham iTBS) - 1) cigarette cue AB measured with eye tracking (gaze fixation time), 2) opioid cue AB measured with eye tracking, 3) cigarette craving assessed using the short form version of tobacco craving questionnaire (TCQ-SF), and 4) opioid craving assessed using the opioid craving scale (OCS). Dataset Description. The dataset comprises 4 sheets. Sheet one comprises cigarette cue attentional bias data, sheet two comprises opioid cue attentional bias data, sheet three comprises cigarette craving data, and sheet four comprises opioid craving data.

Files

Steps to reproduce

The Microsoft Excel data file has four sheets. Sheet one comprises cigarette cue attentional bias data, sheet two comprises opioid cue attentional bias data, sheet three comprises cigarette craving data, and sheet four comprises opioid craving data.

Institutions

  • University of Kentucky College of Medicine

Categories

Transcranial Magnetic Stimulation, Opioid, Tobacco, Craving, Attentional Bias

Funders

  • Substance Use Priority Research Area (SUPRA) Pilot Award
  • CCSG Pilot Award, Markey Cancer Center, University of Kentucky College of Medicine

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