The data are used for the study of Van Drone Routing Problem with Multiple Delivery Points and Cooperation (VDRPMDPC). The excel (.xlsx) files contains the road distances between 40, 60, 100 clients placed in Western Attica. Also, contains the Euclidian distances for the same clients. The road distances are used from the vehicles and the Euclidian distances from the drones. Finally, the word (.doc) file is the explanation memo for the excel files.