Differential protein degradation with a super-degron tag and thalidomide analogs

Description

Differential protein degradation with a super-degron tag and thalidomide analogs: EGFP is degraded in wild-type mouse cell, while PD-1 requires CRBN humanization, providing new insights into T cell regulation.

Institutions

• Kyoto Daigaku

  Kyoto

Categories

Funders

• Japan Society for the Promotion of Science

  Tokyo, Japan

  Grant ID: JP20H03171
• Japan Society for the Promotion of Science

  Tokyo, Japan

  Grant ID: JP21K19188
• Japan Society for the Promotion of Science

  Tokyo, Japan

  Grant ID: JP22H04922
• Kyoto University

  Kyoto, Japan

  Grant ID: 2025Y

Licence