Astrocytic corticosteroids and immunity

Published: 6 October 2023| Version 1 | DOI: 10.17632/mr9zz4wbfb.1
Contributors:
Lai Wenfang, Siying Huang, Junjie Liu, Binbin Zhou, Zhengshuang Yu, John Brown, Guizhu Hong

Description

Reactive astrocytes are important pathophysiologically and synthesise neurosteroids. We observed that LPS increased immunoreactive TLR4 and key steroidogenic enzymes in cortical astrocytes of rats and investigated whether corticosteroids are produced and mediate astrocytic TLR4-dependent innate immune responses.

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Categories

Astrocyte Response to Injury

Funding

National Natural Science Foundation of China

81973503

National Natural Science Foundation of China

82174001

Fujian Provincial Department of Science & Technology, China

2019J01345, 2020J01727 & 2021J02014

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