Astrocytic corticosteroids and immunity
Published: 6 October 2023| Version 1 | DOI: 10.17632/mr9zz4wbfb.1
Contributors:
Lai Wenfang, Siying Huang, Junjie Liu, Binbin Zhou, Zhengshuang Yu, John Brown, Guizhu HongDescription
Reactive astrocytes are important pathophysiologically and synthesise neurosteroids. We observed that LPS increased immunoreactive TLR4 and key steroidogenic enzymes in cortical astrocytes of rats and investigated whether corticosteroids are produced and mediate astrocytic TLR4-dependent innate immune responses.
Files
Categories
Astrocyte Response to Injury
Funding
National Natural Science Foundation of China
81973503
National Natural Science Foundation of China
82174001
Fujian Provincial Department of Science & Technology, China
2019J01345, 2020J01727 & 2021J02014