Organic-inorganic hybrid based on Laponite as a platform for controlled release of 5-fluorouracil: characterization and release mechanism

Published: 27 November 2025| Version 1 | DOI: 10.17632/mtds4ckns5.1
Contributors:
Bruno Seiki Domingos Onishi, Marina Abuçafy, Silvia Santagneli, Ana Luísa Rodriguez Gini, Pamela Souza Tada da Cunha, Jean Dos Santos, Cauê Benito Scarim, Sidney Ribeiro

Description

In this study, we developed an organic–inorganic hybrid based on Laponite (synthetic clay mineral) modified with APTES ((3-aminopropyl)triethoxysilane) to enhance the controlled release of 5-FU. The structural features of the hybrid are designed to improve drug loading efficiency and modulate the release profile by optimizing interactions between the drug and the modified clay. Comprehensive characterization was performed to elucidate the structural, morphological, and chemical modifications induced by APTES, followed by investigation of the release kinetics and underlying release mechanism. In addition, in vitro cell viability assays and HET Cam assays were conducted to evaluate the biocompatibility of the developed system and assess its potential for biomedical applications. The datas is related to the raw data obtained from characterization of Laponite, Laponite modified with APTES and the hybrid loaded with 5-Fluororacil. As well as the release assay, models used, cell vilability and HET-CAM analysis. The raw datas is in workbooks at Origin Project (.opju) file; Sigma Plot (pzfx); txt, xlsx, docx and pdf.

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Institutions

  • Universidade de Sao Paulo Instituto de Quimica de Sao Carlos
  • Universidade Estadual Paulista Julio de Mesquita Filho
  • Universidade Estadual Paulista Julio de Mesquita Filho Faculdade de Ciencias Farmaceuticas Campus de Araraquara

Categories

Chemistry, Materials Science, Organic-Inorganic Hybrid Material, Clay Mineral, Pharmaceutics

Funders

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