MR Imaging raw data collected on Bruker 7T for chemotherapy induced neuropathic pain.
Description
Neuropathic pain is an unfortunate side-effect in the use of chemotherapy for the treatment of cancer. To date there have been no reports using imaging to characterize chemo-therapy induced neuropathy. To that end, we used the common chemotherapy paclitaxel to induced cold allodynia followed by different MRI protocols to show a rapid reorganization of brain neural circuits. Rats received either paclitaxel (2 mg/kg/day i.p.; cumulative dose of 8 mg/kg) or its cremophor-based vehicle four times on alternate days (i.e. day 0, 2, 4, 6). At the cessation of treatments, rats were tested for cold allodynia followed by diffusion weighted magnetic resonance imaging and resting state functional connectivity. Imaging data was analyzed using a 3D MRI rat with 173 segmented and annotated brain areas. Paclitaxel treated rats were significantly more sensitive to a cold stimulus as compared to controls. Diffusion weighted imaging identified a constellation of brain areas e.g. prefrontal ctx, amygdala, hippocampus, hypothalamus and the striatal/accumbens dopaminergic system involved in the emotional and motivations response to chronic pain. This putative reorganization of gray matter microarchitecture forms a continuum of brain areas stretching from the basal medial/lateral forebrain to the midbrain. Resting state functional connectivity showed reorganization between the periaqueductal gray, a key node in pain neural circuitry, and connections to the brainstem. The data included has two groups. Group A is Control, Group B is treatrd with Paclitaxel. Data included in this folder is in original Bruker format. If you need any conversion help please contact Praveen Kulkarni (p.kulkarni@Northeastern.edu) Each study has Following scans, scan number may vary for study and can be determined from method file. 1) DWI : DTIEPI scan with 10 directions 2 averages and B=1000. 2) Resting state scan 1: 3 segment EPI, TR: 1sec 10 min scan. 3) Resting state scan 2: 3 segment EPI, TR: 1sec 10 min scan. 4) T2 weight high res Anatomy scan.