Expression data from major metabolic organs of C57BL/6J mice and MIN6 cells maintained on normal or stressed conditions

Description

We studied the novel mechanism of ER quality control, ER homeostasis maintenance and functional plasticity in pancreatic β-cells to increase systemic glucose homeostasis against progression of type 2 diabetes. In RNA-Seq dataset, we provided islets' RNA-Seq for C57BL/6J wildtype mice on 2-month high-fat diet and on normal chow diet; we also provided 10 different metabolic tissues' RNA-Seq for C57BL/6J wildtype mice on normal chow diet. In proteomics dataset, we provided proteomic analysis on MIN6 cells and supernatant on normal and stressed culturing conditions; we also provided islets' proteomic analysis for C57BL/6J wildtype mice on 2-month high-fat diet and on normal chow diet; we also provided proteomic analysis for DNA-pull down-protein complex from HEK293T cells; we also provided proteomic analysis for streptavidin pulldown proteins from MIN6 cells BioID. In CUT&Tag-Seq dataset, we provided MAZ CUT&Tag on HEK293T cells. Original computational code for image processing were deposited in this dataset. All the algorithms were implemented with OpenCV and Numpy library in Python.

Institutions

• Zhejiang University

  Zhejiang, Hangzhou

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