Functional characterization of BAP1 mutations in genome edited cholangiocarcinoma organoids: role in cell death and drug responses

Name: Functional characterization of BAP1 mutations in genome edited cholangiocarcinoma organoids: role in cell death and drug responses
Creator: Wunan Mi
Published: 2025-10-10T09:45:15.329Z
Keywords: Genome Editing

Mi, Wunan; Shi, Shaojun; Schene, Imre; Joore, Indi; Roest, Henk; Fuchs, Sabine; van der Laan, Luc; Verstegen, Monique

doi:10.17632/nvg7zsz27v.1

Functional characterization of BAP1 mutations in genome edited cholangiocarcinoma organoids: role in cell death and drug responses

Published: 10 October 2025| Version 1 | DOI: 10.17632/nvg7zsz27v.1

Contributors:

Wunan Mi, Shaojun Shi, Imre Schene, Indi Joore, Henk Roest, Sabine Fuchs, Luc van der Laan, Monique Verstegen

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This dataset contains the RNA-seq data used in the study titled “Functional characterization of BAP1 mutations in genome edited cholangiocarcinoma organoids: role in cell death and drug responses.” Organoids derived from cholangiocarcinoma patients were genome-edited to model different BAP1 statuses (wild-type and mutant, three dupalication for every group). RNA was extracted and sequenced to explore BAP1-dependent transcriptional changes.

Functional characterization of BAP1 mutations in genome edited cholangiocarcinoma organoids: role in cell death and drug responses

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