SKD Regulates NRF2/NF-κB Axis to Ameliorate Diabetic Liver Injury
Published: 15 September 2025| Version 1 | DOI: 10.17632/p288psb263.1
Contributor:
婉莹 徐Description
This data demonstrates the potential mechanism by which SKD ameliorates diabetic liver injury in zebrafish model transcriptome sequencing. Raw sequencing data were processed using R (v4.1.2), removing adapter sequences, low-quality reads (Q < 20), and reads containing over 5% undefined bases (N), thereby yielding high-quality cleaned data. Differential gene expression analysis was performed using DESeq2, defining significantly differentially expressed genes (DEGs) as those with |log₂ fold change| > 2 and an adjusted P < 0.05. The top 30 DEGs underwent hierarchical clustering using the heatmap package. KEGG pathway enrichment analysis was conducted with KOBAS (P < 0.05), with results visualised using ggplot2 (v4.1.2).
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Institutions
- Zhejiang Chinese Medical University
Categories
Traditional Medicine