Effect of Ginkgo Biloba Extract on TGF-β1-induced Myocardial Fibroblast Fibrosis in Neonatal Rats
Description
This dataset contains immunohistochemical detection and analysis of the MMPs system (including significant reduction in the secretion and deposition of collagen I and III, significant reduction in the expression levels of MMP-2 and MMP-9, and significant inhibition of TIMP-1 expression) in cardiac fibroblasts
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This investigation revealed that TGF-β1 can promote the proliferation of CFb, which can be strongly inhibited by GBE, the considerable reduction in the expression of TGF-β1, and type I and III collagen secretion and deposition, the MMP-2 and MMP-9 expressions, which hindered the expression of TIMP-1.
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Funding
the Education Department of Guizhou Province KY(2016)070
The Science and Technology Department of Guizhou Province（2019）2800
Science and Technology Research Project of Guizhou Administration of Traditional Chinese Medicine QZYY2017-026
The Science and Technology Department of Guizhou Province Platform for talents (2018)5608
Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2019PT320003)