Investigation the number and structure of chromosomes in men from infertility couples: a massive prospective study

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This retrospective study enrolled men from infertile couples at the Military Institute of Clinical Embryology and Andrology and Fertility Hospital of Hanoi between January 2020 and December 2023. A total of 18,584 male subjects were included. Karyotyping was performed to identify numerical and structural chromosomal abnormalities. Variations in heterochromatin length were also reported. In cases where karyotyping indicated a structural deletion on the Y chromosome, multiplex polymerase chain reaction (PCR) was used to detect Y chromosome microdeletions. Data were analyzed using STATA 16.0 software.

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