Raw DNA Methylation Data; Reese et al., 2023
Description
In this study, we present a case of synchronous double pituitary prolactinomas in a 29-year-old female with suboptimal response of prolactin levels and tumor shrinkage associated with cabergoline intolerance. Raw cfDNA methylation intensity data files (*.idat) for 4 liquid biopsy (surgical and follow-up blood serum & plasma) and 4 FFPE collections from pituitary neuroendocrine tumors (PitNETs) and non-tumorous conditions.
Files
Steps to reproduce
library(minfi) idat <- read.metharray.exp(targets = NULL,base=getwd(),recursive = TRUE) proc <- preprocessNoob(idat, offset = 0, dyeCorr = TRUE, verbose = TRUE, dyeMethod="reference") detP <- detectionP(idat, type = "m+u") proc.r <- ratioConvert(proc) is.na(assays(proc.r)$Beta) <- (detP[rownames(proc.r), colnames(proc.r)] > 1E-16) beta <- assays(proc.r)$Beta