Raw DNA Methylation Data; Reese et al., 2023

Published: 29 August 2023| Version 1 | DOI: 10.17632/pxxzdrfs8r.1
Contributors:
Grayson Herrgott,

Description

In this study, we present a case of synchronous double pituitary prolactinomas in a 29-year-old female with suboptimal response of prolactin levels and tumor shrinkage associated with cabergoline intolerance. Raw cfDNA methylation intensity data files (*.idat) for 4 liquid biopsy (surgical and follow-up blood serum & plasma) and 4 FFPE collections from pituitary neuroendocrine tumors (PitNETs) and non-tumorous conditions.

Files

Steps to reproduce

library(minfi) idat <- read.metharray.exp(targets = NULL,base=getwd(),recursive = TRUE) proc <- preprocessNoob(idat, offset = 0, dyeCorr = TRUE, verbose = TRUE, dyeMethod="reference") detP <- detectionP(idat, type = "m+u") proc.r <- ratioConvert(proc) is.na(assays(proc.r)$Beta) <- (detP[rownames(proc.r), colnames(proc.r)] > 1E-16) beta <- assays(proc.r)$Beta

Institutions

Henry Ford Health System

Categories

Methylation, Blood, Epigenetics, Pituitary Tumor

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