SIRT2 transgenic over-expression does not impact lifespan in mice - associated data
Published: 2 November 2023| Version 1 | DOI: 10.17632/rdwgnfh23g.1
Contributor:
Lindsay WuDescription
Raw data and accompanying R code for analysis and creating figures for the manuscript "SIRT2 transgenic overexpression does not impact lifespan in mice" by Wu LE et al, Aging Cell 2023 (doi: 10.1111/acel.14027). This was a study of lifespan and age-related healthspan in a strain of SIRT2 transgenic mice, showing no impact from the SIRT2 transgene.
Files
Steps to reproduce
Open the accompanying R script in RStudio in a new root folder, where the accompanying CSV files should be dropped. The code is annotated to recreate each figure and analysis, highlight each section and hit ctrl-enter to run code.
Institutions
- Victor Chang Cardiac Research Institute
- University of New South Wales
Categories
Aging, Life-Span, Healthy Ageing, 13C NMR Spectroscopy
Funders
AM Process Data Template
| Additive Manufacturing Process | NA |
| Process Parameters | NA |
| Process Date | 2023-11-02T00:00:00.000Z |
| Process Description | NA |
| CAD File | NA |
| Process ID | NA |
Ex-situ Characterization Data Template
| Sample ID | |
| Process ID | |
| Characterization Type | |
| Characterization Instrument | Not relevant |
| Ex-situ Measurement Details |
In-situ Characterization Data Template
| Sample ID | |
| Process ID | |
| Characterization Type | |
| Characterization Instrument | N/A |
| In-situ Measurement Details |
Research Process Flow
| Process Flow for Additive Manufacturing | |
| Process Flow for Ex-situ Characterization | |
| Process Flow for In-situ Characterization | |
| Process Flow for Computational Modeling |
Software
| Available Software | |
| Type | Public Domain |
| Contact link |
Publications
| Sample ID | |
| Publication Title | SIRT2 transgenic over‐expression does not impact lifespan in mice |
| Publication DOI | 10.1111/acel.14027 |
| Citation | Wu LE et al "SIRT2 transgenic over‐expression does not impact lifespan in mice", Aging Cell 2023 |
| Authors | Wu, Lindsay E. |
AM Sample Data Template
| Sample ID | NA |
| Date | 2023-11-02T00:00:00.000Z |
| Alloy Type | Fe-Base |
| Alloy composition | NA |
| Alloy certificate | NA |
| Process ID | NA |
MURI/AUSMURI University
| User Name | |
| University | UNSW Sydney |
| Address | University of New South Wales, Kensington 2052, NSW, Australia |
| Acknowledgement | LEW is supported by an American Federation for Aging Research (AFAR)/Hevolution New Investigator award. This work was supported by the National Health and Medical Research Council (NHMRC) of Australia, through project grant APP1066172 and fellowship APP1127821. |
Patents
| Patent Title | |
| Patent Application |
Computational Modelling
| Objective of the Model | |
| Typical Input | |
| Typical output | |
| Computer System Requirements | |
| Simulation ID |
Hardware
| Available Hardware | |
| Accessibility | |
| Contact link |