Importin-8 silencing reduces Ataxin-3 aggregation and alleviates Machado-Joseph disease/Spinocerebellar ataxia type 3

Name: Importin-8 silencing reduces Ataxin-3 aggregation and alleviates Machado-Joseph disease/Spinocerebellar ataxia type 3
Creator: Inês Morgado Martins
Published: 2026-03-09T10:44:04.773Z
Keywords: Data Access, Biomedical Research

Morgado Martins , Inês; Sergeevna Sowa, Anna; Rufino-Ramos, David; Duarte Lobo, Diana; Leandro, Kevin; Vasconcelos-Ferreira, Ana; Pereira, Dina; Riess, Olaf; Schmidt, Thorsten; Pereira de Almeida, Luis

doi:10.17632/s2ng8g5745.1

Importin-8 silencing reduces Ataxin-3 aggregation and alleviates Machado-Joseph disease/Spinocerebellar ataxia type 3

Published: 9 March 2026| Version 1 | DOI: 10.17632/s2ng8g5745.1

Contributors:

,

, Luis Pereira de Almeida

Description

Dataset for: Importin-8 silencing reduces Ataxin-3 aggregation and alleviates Machado-Joseph disease/Spinocerebellar ataxia type 3 This repository contains the supplementary data and unprocessed raw datasets supporting the study of nucleocytoplasmic transport dysregulation in Machado–Joseph disease (MJD). The research identifies Importin-8 (Ipo8) as a key modulator of Ataxin-3 (Atxn-3) aggregation and neuronal dysfunction.

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University of Coimbra
Coimbra, Coimbra
University of Tübingen
Baden-Wurttemberg, Tübingen

Importin-8 silencing reduces Ataxin-3 aggregation and alleviates Machado-Joseph disease/Spinocerebellar ataxia type 3

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