The lung commensal Lactobacillus protects against bacterial pulmonary infections by driving an interleukin-17 response from mucosal Vγ4+γδ T cells.
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16S Ribosomal DNA Gene Sequencing, Transcriptomics analysis, ELISA, Flow cytometric and other methods were used in this study.All experiments were performed in triplicate. GraphPad software program was used for data processing and analysis. Significance of differences with p< 0.05 was determined by analysis of variance (ANOVA). Differences among three or more groups were analyzed by one- or two-way ANOVA multiple comparisons. Significance of differences was classified as *p< 0.05, **p< 0.01, ***p< 0.001, or n.s. (not significant).
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Funding
Science and Technology Major Project of the Inner Mongolia Autonomous Region of China
2021ZD0013
Key Scientific and Technological Research Program of Inner Mongolia Autonomous Region
2021GG0156
National Natural Science Foundation of China
32060800
Technology Major Project of Hohhot
2023-JieBangGuaShuai
China Postdoctoral Science Foundation
2023MD734180