HPV sequencing in Indian buccal mucosa cancer tumour tissues
Description
Over 150 genotypes of Human Papillomavirus (HPV) are identified to date, which is a common virus spread by skin-to-skin contact, especially sexual activity. Common high-risk HPV subtypes (HR-HPV) like HPV 16 and HPV 18 are found to play a direct role in development of cervical cancers. Among head and neck cancers, these HR-HPV are also a well-known risk factor for oropharyngeal cancers (OPC). But their exact role in oral cavity cancers (OC) is not known. There exists several literature exploring the difference in survival rates of HPV-related OPCs versus non-HPV-related OPCs, and this is what was aimed at observing among the OC patients in our Indian population as well. A lot of non-HPV Sexually Transmitted Infections (STIs) are also found at the tumour sites of a lot of oral cancer patients, which was also aimed to be explored in this study. The prevalence of HPV specifically has shown to vary a lot over the years. But as per latest studies, among head and neck cancers, the prevalence ranged between 3-13%, with the lowest being among the OC patients.
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Institutions
- Tata Memorial Center