LIFR antagonism reverses epithelial pro-CAF programs in pancreatic ductal adenocarcinoma

Published: 24 November 2025| Version 1 | DOI: 10.17632/sj3xhvmz44.1
Contributors:
Cristina Di Giorgio, silvia marchianò, Michele Biagioli, Stefano Fiorucci

Description

In PDAC cancer cells, MIAPaCa-2 cells, LIF induced a coordinated transcriptional network encompassing inflammatory mediators, paracrine fibroblast-activating signals and ECM/mechanotransductive modules, while repressing stromal-inhibitory genes. These signatures were recapitulated in PDAC tissues, where LIF expression directly correlated with CAF, iCAF and myCAF markers and with stromal remodelling genes.

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Institutions

  • Universita degli Studi di Perugia Dipartimento di Medicina

Categories

Pancreatic Cancer, Transcriptome, Pancreas

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