A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity
Published: 18 October 2021| Version 1 | DOI: 10.17632/srjnx7dcmp.1
Contributors:
, , , , , , , , , , Description
Screen of an actinomycetes library yields antimalarial candidates that are non-toxic. A compound purified from an active extract, PDE-I2, potently inhibits P.falciparum proliferation. GraphPad Prism data are included, supporting figures 4-6, S1,2,4,5, and Table S1
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Institutions
McMaster University Michael G DeGroote Institute for Infectious Disease Research, Bernhard-Nocht-Institut fur Tropenmedizin
Categories
Health Sciences