Data for: Distribution of connective tissue in the male and female porcine liver: Histological mapping and recommendations for sampling of tissue probes

Published: 28-06-2018| Version 1 | DOI: 10.17632/ssgd4mwgsj.1
Contributors:
Zbynek Tonar,
Richard Palek,
Lada Eberlova,
Milena Kralickova,
Patrik Mik,
Kirsti Witter,
Miroslav Jirik,
Hynek Mírka,
Anna Maleckova,
Vaclav Liska

Description

Supplement 1. Primary stereological data on volume fraction of connective tissue and cross-sectional area of classical lobules in all investigated samples. The following abbreviations are used: VV(ICT) – volume fraction of interlobular connective tissue (connective tissue surrounding liver lobule), VV(PSCT) – volume fraction of perisinusoidal connective tissue (connective tissue located at the lobular sinusoids), VV(PCCT) – volume fraction of pericentral connective tissue (connective tissue surrounding central vein), VV(CT) – volume fraction of total connective tissue (sum of all connective tissue volume fractions). Supplement 2. Calculating sample sizes needed to detect a certain expected relative increase in the connective tissue fraction in various hepatic lobes. VV(CT) – volume fraction of connective tissue (total connective tissue irrespective of its localization), n – number of tissue blocks in each of the groups that are to be compared. Sample sizes were calculated according to Chow et al. (power=0.8; significance level=0.05) (2008). The data are presented for both sexes. Supplement 3. Calculating sample size needed to detect a certain expected relative increase in the connective tissue fraction in various regions of interests (ROIs) within hepatic lobes. Peripheral ROI – region at the periphery of a liver lobe, paraportal ROI – region of a lobe near the porta hepatis, paracaval ROI – region of a lobe adjacent to the caudal vena cava, VV(CT) – volume fraction of connective tissue (total connective tissue irrespective of its localization), n – number of tissue blocks in each of the compared groups. Sample size were calculated according to Chow et al. (power=0.8; significance level=0.05) (2008). The data are presented for both sexes and each ROI within each hepatic lobe.

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