PHARMIP
Published: 2 December 2019| Version 1 | DOI: 10.17632/t26pp5y6ym.1
Contributors:
Ahmad Zidan, Eman Saad, Nasser Ibrahim, Amal Mahmoud, Medhat Hashim, Alaa HemeidaDescription
1-Files that resulted from application of PHARMIP insilico method to explore adverse drug reactions on 2 examples of domperidone related cardio-toxicity and ranitidine related thrombocytopenia . 2-Files that are used to apply the step of molecular docking on the previous examples.
Files
Steps to reproduce
1- Use drug SMILES code to predict targets via SwissTargetPrediction, SEA server, Poly Pharmacology browser. 2- Use drug SDF file to predict targets using PharMapper. 3- Get and refine the whole off-label targets list (OLT). 4- Use the OLT list to retrieve the diseases associated (DA) to the list via DisGeNet. 5- Filter the DA list with the disease of interest.
Institutions
University of Sadat City
Categories
Bioinformatics, Pharmacogenetics, Pharmacovigilance