Elevated myocardial SORBS2 and the underlying implications in left ventricular noncompaction cardiomyopathy

Published: 7 January 2020| Version 1 | DOI: 10.17632/v3k385htnt.1
Contributor:
Yingjie Wei

Description

A proteomics analysis seeking to identify proteins differentially accumulated in heart tissues of patients with Left Ventricular Noncompaction Cardiomyopathy (LVNC; 8 samples), Hypertrophic Cardiomyopathy (HCM; 7 samples), and Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC; 8 samples) (Figure 1A). Our comparative analysis of the four sample types identified which proteins were significantly up-regulated (fold change>1.2) and down-regulated (fold change<0.83) in LVNC, HCM, and ARVC hearts.

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Steps to reproduce

Protein extraction and digestion, TMT Labeling ,Two-Dimensional Liquid Chromatography-Tandem Mass Spectrometry (2D LC-MS/MS)

Institutions

Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital

Categories

Proteomics

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