LINC00174 in Nasopharyngeal Carcinoma: Expression Profiles and Correlations with Histopathological Features
Description
Nasopharyngeal carcinoma (NPC) is an aggressive epithelial malignancy with high regional prevalence and unsatisfactory clinical outcomes, largely due to the lack of reliable diagnostic biomarkers and effective targeted therapies. This study aimed to investigate the expression patterns of long non coding RNA LINC00174, microRNA 3713 (miR 3713), and targeting protein for Xklp2 (TPX2) in NPC, and to analyze their associations with key histopathological features, including tumor differentiation and nuclear atypia.Our findings indicate that the LINC00174/miR 3713/TPX2 axis is coordinately dysregulated in NPC and closely associated with aggressive histopathological characteristics. This regulatory axis may serve as a promising candidate biomarker panel for pathological evaluation and a potential therapeutic target for NPC.