A microbial derived bile acid acts as GPBAR1 agonist and RORγt inverse agonist and reverses inflammation in inflammatory bowel disease: binding modes retrieved from molecular docking calculations

Published: 25 March 2024| Version 1 | DOI: 10.17632/vdkn2x9g8n.1
Contributors:
Bianca Fiorillo,

Description

The interplay between the gut microbiota, bile acids and the immune is a critical determinant in the development of inflammatory bowel disease (IBD). Here, we investigated the binding modes of five bile acid derivatives to RORgt and GPBAR1.

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Institutions

Universita degli Studi di Napoli Federico II Dipartimento di Farmacia

Categories

Nuclear Receptor, G Protein-Coupled Receptor, Bile Acid, Molecular Docking, Computational Chemistry

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