Carnosine Attenuates Methotrexate-Induced Hepatotoxicity by Reducing Oxidative Stress, Inflammation, and Apoptosis: Raw Data
Description
Raw data underlying the study “Carnosine Attenuates Methotrexate-Induced Hepatotoxicity by Reducing Oxidative Stress, Inflammation, and Apoptosis.” The dataset contains individual-level experimental data from male Wistar albino rats assigned to four experimental groups: Control, Methotrexate (MTX), Carnosine (CAR), and Methotrexate + Carnosine (MTX+CAR). The dataset includes serum biochemical parameters (AST and ALT), liver tissue biochemical parameters (TOS, TAS, OSI, TNF-alpha, and TGF-beta1), liver tissue gene expression data (NRF2, HO-1, BCL-2, and BAX), and histopathological/immunohistochemical findings (degeneration, necrosis, and Caspase-3 immunohistochemistry scores). Data are provided as individual animal-level raw measurements and are organized into separate worksheets according to the type of analysis. No patient or human subject data are included.
Files
Steps to reproduce
Male Wistar Albino rats were randomly assigned to four experimental groups: Control, Methotrexate (MTX), Carnosine (CAR), and MTX+Carnosine (MTX+CAR). Carnosine was administered intraperitoneally at 100 mg/kg/day for 24 days. A single dose of methotrexate (20 mg/kg, intraperitoneally) was administered on day 21. Animals were sacrificed on day 25, and blood and liver tissue samples were collected. Serum biochemical parameters, liver tissue biochemical parameters, gene expression, histopathological findings, and Caspase-3 immunohistochemistry scores were obtained using the procedures described in the associated manuscript. The dataset contains the individual animal-level raw measurements used for statistical analyses.
Institutions
- Süleyman Demirel UniversityIsparta, Isparta