Role of HMGB1/NF-κB/NLRP3 signaling pathway in silicosis combined COPD

Published: 30 December 2025| Version 2 | DOI: 10.17632/vhz7km2w3t.2
Contributor:
Mengya Shi

Description

Our results revealed GA as HMGB1 inhibitor that could suppress fibrotic progression and alleviate inflammatory in silicosis complicated with COPD through inhibiting fibrosis-related proteins including Vimentin and α-SMA expression in the lung tissue of rat model. HMGB1, NLRP3, NF-κB-p-p65 were activated in silicosis complicated with COPD, which was suppressed by GA treatment in vivo. Furthermore, HMGB1, NLRP3, NF-κB-p-p65 were increased in silicosis complicated with COPD patients.

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