Pan-MKK inhibition by myricetin disrupts microglial p38 signaling to rescue sleep deprivation-induced neuropsychiatric disturbances
Published: 10 February 2026| Version 1 | DOI: 10.17632/vzrmtkcs7f.1
Contributor:
Xiaoqing Huang Description
We delineate the molecular pathogenesis of SD-induced neuropsychiatric impairments and establish SX as a multi-target therapeutic intervention. SX corrects behavioral deficits by suppressing hippocampal microglial M1 polarization through inhibition of p38 phosphorylation. Crucially, we identify myricetin as a novel broad-spectrum inhibitor of microglial p38 activation that directly binds p38 and disrupts MKK-mediated phosphorylation, serves as primary active constituent of SX against SD pathology.
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Institutions
- Xiamen UniversityFujian, Xiamen
Categories
Sleep