Overactive mitochondrial DNA replisome causes neonatal heart failure via ferroptosis - Supplemental data

Published: 7 December 2023| Version 2 | DOI: 10.17632/wm2dhwpghm.2
Contributors:
, Tuomas Laalo, Steffi Goffart, Riikka Kivelä, Karlo Skube, Anni I Nieminen, Sara Wickström, James Stewart, Anu Suomalainen

Description

Characterization and multi-omics analysis of the hearts of mice carrying an exonuclease-deficient DNA polymerase gamma and overexpressing Twinkle helicase. Includes numeric values used for plots, uncropped and representative echocardiography videos and transmission electron micrograms, and data from mitochondrial DNA deep-sequencing, transcriptomic, metabolomic, proteomic analyses. For further methodological details please refer to the associated original publication.

Files

Steps to reproduce

See related original publication of the same name.

Institutions

Helsingin Yliopisto, Jyvaskylan Yliopisto, Wellcome Trust Centre for Mitochondrial Research, Ita-Suomen yliopisto, Wihurin Tutkimuslaitos, Newcastle University

Categories

Proteomics, Metabolomics, Transcriptomics, Echocardiography, Physiological Measurement, mtDNA

Licence