Overactive mitochondrial DNA replisome causes neonatal heart failure via ferroptosis - Supplemental data

Published: 6 April 2022| Version 1 | DOI: 10.17632/wm2dhwpghm.1
Contributors:
,
Tuomas Laalo,
Steffi Goffart,
Riikka Kivelä,
Karlo Skube,
Anni I Nieminen,
Sara Wickström,
James Stewart,
Anu Suomalainen

Description

Characterization and multi-omics analysis of the hearts of mice carrying an exonuclease-deficient DNA polymerase gamma and overexpressing Twinkle helicase. Includes numeric values used for plots, uncropped and representative echocardiography videos and transmission electron micrograms, and data from mitochondrial DNA deep-sequencing, transcriptomic, metabolomic, proteomic analyses. For further methodological details please refer to the associated original publication.

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Steps to reproduce

See related original publication of the same name.

Institutions

Helsingin Yliopisto, Jyvaskylan Yliopisto, Ita-Suomen yliopisto, Wihurin Tutkimuslaitos, The University of Newcastle

Categories

Metabolomics, DNA Sequencing, Transcriptomics, Physiological Measurement, mtDNA, Expression Proteomics

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