USP1 inhibition promotes RAD18-dependent PCNA degradation and BRCA1 synthetic lethality

Name: USP1 inhibition promotes RAD18-dependent PCNA degradation and BRCA1 synthetic lethality
Creator: Nicholas Ashton
Published: 2026-05-09T01:38:34.908Z
Keywords: Biochemistry, Biophysics

Ashton, Nicholas; Ravindranathan, Ramya; Korchak, Emilie

doi:10.17632/wv5p74n2vj.1

USP1 inhibition promotes RAD18-dependent PCNA degradation and BRCA1 synthetic lethality

Published: 9 May 2026| Version 1 | DOI: 10.17632/wv5p74n2vj.1

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Uncropped immunoblot images, clonogenic and PLA assay quantification, and generated AlphaFold models

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Dana-Farber Cancer Institute
Massachusetts, Boston
UConn Health
Connecticut, Farmington

USP1 inhibition promotes RAD18-dependent PCNA degradation and BRCA1 synthetic lethality

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