Intergrated Multi-omics Sequencing Reveals Metabolic Reprograms in the Progression of ccRCC

Published: 26 June 2023| Version 1 | DOI: 10.17632/x4krt22tf4.1
Contributor:
Junyi Hu

Description

100 samples from treatment-naive ccRCC patients and 50 matched normal adjacent tissues (NATs) were profiled with whole exon sequencing (WES), whole transcriptome sequencing (WTS), data-independent acquisition (DIA)-based proteome and untargeted metabolome technology to identify the general molecular characteristics of the TJ-RCC cohort. Single-nucleic RNA sequencing, single-nucleic multiome, spatial transcriptome and spatial metabolome were performed on part of these 100 tumors to detail the ITH inside ccRCC.

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Institutions

  • Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology

Categories

Cancer, DNA Sequencing, Renal Cell Carcinoma, Single-Cell RNA Sequencing

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