Glucagon-like peptide alters hepatic ketone metabolism in the Pacific spiny dogfish

Description

No effects of chondrichthyan glucagon-like peptide were found on spiral valve. GLP-3 exerts metabolic effects on ketone, but not glucose liver metabolism, as shown by a switch from endogenous consumption to production of ketones, paired with increases in transcript abundance of putative ketone transporters and the activity of B-hydroxybutyrate dehydrogenase in the liver. Unique actions indicate early putative actions of GLP in vertebrate evolution.

Institutions

• University of Manitoba

  MB, Winnipeg

Categories

Funders

• Natural Sciences and Engineering Research Council

  Ontario, Canada

  Grant ID: 05348-15

Licence