Glucagon-like peptide alters hepatic ketone metabolism in the Pacific spiny dogfish

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No effects of chondrichthyan glucagon-like peptide were found on spiral valve. GLP-3 exerts metabolic effects on ketone, but not glucose liver metabolism, as shown by a switch from endogenous consumption to production of ketones, paired with increases in transcript abundance of putative ketone transporters and the activity of B-hydroxybutyrate dehydrogenase in the liver. Unique actions indicate early putative actions of GLP in vertebrate evolution.

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