Glucagon-like peptide alters hepatic ketone metabolism in the Pacific spiny dogfish
No effects of chondrichthyan glucagon-like peptide were found on spiral valve. GLP-3 exerts metabolic effects on ketone, but not glucose liver metabolism, as shown by a switch from endogenous consumption to production of ketones, paired with increases in transcript abundance of putative ketone transporters and the activity of B-hydroxybutyrate dehydrogenase in the liver. Unique actions indicate early putative actions of GLP in vertebrate evolution.
Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada