Salidroside project

Published: 20 August 2024| Version 1 | DOI: 10.17632/x8stnrtfrj.1
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Description

The project tested primarily the influence of salidroside on cytochrome P450 metabolic activities and a possible mechanism of induced changes. The rats were treated with salidroside at the doses from 5 to 45 mg/kg/day for 7 consecutive days. The liver microsomes were isolated and tested for P450 metabolic activities with specific substrates. In vitro inhibition studies with human liver microsomes and naive rat liver microsomes were also performed.

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Institutions

  • Masarykova univerzita Lekarska fakulta

Categories

Pharmacokinetics, Drug Safety, Drug Metabolism through Cytochrome P450

Funders

  • Ministry of Education, Youth and Sports, Czech republic
    Grant ID: MUNI/A/1440/2021
  • Ministry of Education, Youth and Sports, Czech republic
    Grant ID: MUNI/A/1342/2022
  • Lékařská fakulta, Masarykova univerzita
    Czechia
    Grant ID: MUNI/IGA/1261/2020
  • RECETOX
    Czechia
    Grant ID: LM2023069
  • RECETOX
    Czechia
    Grant ID: ELIXIR CZ LM2023055
  • Ministry of Education, Youth and Sports, Czech republic
    Grant ID: INFRA CZ LM2018140
  • Central European Institute of Technology
    Czechia
    Grant ID: LM2018132

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