Salidroside project

Published: 27 August 2024| Version 2 | DOI: 10.17632/x8stnrtfrj.2
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Description

The project tested primarily the influence of salidroside on cytochrome P450 metabolic activities and a possible mechanism of induced changes. The rats were treated with salidroside at the doses from 5 to 45 mg/kg/day for 7 consecutive days. The liver microsomes were isolated and tested for P450 metabolic activities with specific substrates. In vitro inhibition studies with human liver microsomes and naive rat liver microsomes were also performed.

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Institutions

Masarykova univerzita Lekarska fakulta

Categories

Pharmacokinetics, Drug Safety, Drug Metabolism through Cytochrome P450

Funding

RECETOX Přírodovědecké Fakulty Masarykovy Univerzity

ELIXIR CZ LM2023055

Lékařská fakulta, Masarykova univerzita

MUNI/IGA/1261/2020

Central European Institute of Technology

LM2018132

Ministry of Education, Youth and Sports, Czech republic

MUNI/A/1440/2021

Ministry of Education, Youth and Sports, Czech republic

INFRA CZ LM2018140

Ministry of Education, Youth and Sports, Czech republic

MUNI/A/1342/2022

RECETOX Přírodovědecké Fakulty Masarykovy Univerzity

LM2023069

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