Salidroside project
Description
The project tested primarily the influence of salidroside on cytochrome P450 metabolic activities and a possible mechanism of induced changes. The rats were treated with salidroside at the doses from 5 to 45 mg/kg/day for 7 consecutive days. The liver microsomes were isolated and tested for P450 metabolic activities with specific substrates. In vitro inhibition studies with human liver microsomes and naive rat liver microsomes were also performed.
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Institutions
Categories
Funding
RECETOX Přírodovědecké Fakulty Masarykovy Univerzity
ELIXIR CZ LM2023055
Lékařská fakulta, Masarykova univerzita
MUNI/IGA/1261/2020
Central European Institute of Technology
LM2018132
Ministry of Education, Youth and Sports, Czech republic
MUNI/A/1440/2021
Ministry of Education, Youth and Sports, Czech republic
INFRA CZ LM2018140
Ministry of Education, Youth and Sports, Czech republic
MUNI/A/1342/2022
RECETOX Přírodovědecké Fakulty Masarykovy Univerzity
LM2023069