Ebselen Restores Colistin Activity Against MCR-1-positive Escherichia coli by Inhibiting MCR-1 and Disrupting Membrane Homeostasis
Published: 19 August 2026| Version 1 | DOI: 10.17632/xvscdcvntj.1
Contributors:
Xiaodan Li, Zhaoran Zhang, Ziyi Zhang, Di Liu, Na Su, Renhang Xiao, Xiangru Wang, Huanchun Chen, , Description
This dataset contains the source and raw data supporting the study on the potentiation of colistin by ebselen against MCR-1-positive Escherichia coli. Source_Data.xlsx provides the individual numerical values underlying all main and supplementary figures. The dataset also includes raw and processed data from antibacterial, enzymatic, biophysical, membrane-permeability, metabolomic, safety, and in vivo experiments. Untargeted metabolomic raw data are provided in mzML format for both positive- and negative-ion modes, together with sample metadata, MD5 checksums, metabolite abundance matrices, annotations, differential-metabolite results, and KEGG enrichment results.
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Institutions
- Huazhong Agricultural UniversityHubei, Wuhan
Categories
Bacterial Pathogen