Alteration of cardiolipin-dependent mitochondrial coupling in muscle protects against obesity
Published: 17 May 2019| Version 1 | DOI: 10.17632/xz5fx4s7x2.1
Contributor:
Fanny Pilot-StorckDescription
Prola et al. show that mitochondria from muscle of Hacd1 knockout mice have altered membranes lipid composition and cristae shape yielding a reduced respiratory efficiency with neither proton leak nor oxidative stress, and consequently leading to an overall increase in energy expenditure that eventually protects against a diet-induced obesity.
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Mitochondrion, Metabolism, Mouse Model