PPARγ/ESCRT – FLSs exosomal ANXA1 – ERK axis Alleviates Chondrocyte Osteoarthritis in Exercise therapy

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Exercise induced PPARγ controls the ESCRT-dependent pathway to activate exosome biogenesis, the exosomal ANXA1 act on chondrocyte to interact with ERK then activate autophagy and ameliorate cartilage degeneration. PPARγ/ESCRT – FLSs exosomal ANXA1 – ERK axis provides a deeper theoretical basis for exercise therapy of OA and a new idea for the clinical transformation of nanoparticles into OA therapy.

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