Supplementary materials - Gut bacterial metabolites and biomarkers of leaky gut in atopic dermatitis
Description
Supplemental Table 1. The list of laboratory parameters investigated in the study. LC-MS – liquid chromatography-mass spectrometry; ELISA – enzyme-linked immunosorbent assay. Supplemental Figure 1. A hypothesis substantiating the concept of the gut-skin axis in atopic dermatitis (left hand side) and a graphical depiction of the study design (right hand side). Dysbiosis of the skin microbiome is associated with altered expression of bacterial metabolites, which may trigger gut barrier impairment. This could lead to systemic inflammation, atopic dermatitis flare-ups and increased risk of food sensitization. The hypothesis was verified in a cross-sectional study of 50 patients with active atopic dermatitis and 25 controls. Bacterial metabolites, biomarkers of gut barrier damage, cytokines and food-specific IgE were analyzed and correlated to clinical characteristics of the study group. AD – atopic dermatitis; EASI – Eczema Area and Severity Index; ELISA – enzyme-linked immunosorbent assay; LC-MS – liquid chromatography-mass spectrometry; SCORAD – SCORing Atopic Dermatitis. Supplemental figure, table, and methods