Determination of mitochondrial functions and damage in kidney in female LeeSung minipigs with a high-fat diet-induced obesity

Name: Determination of mitochondrial functions and damage in kidney in female LeeSung minipigs with a high-fat diet-induced obesity
Creator: Miao-Ju Chien
Published: 2021-06-25T15:13:02.238Z
Keywords: Obesity, Mitochondrion, Kidney Damage

Chien, Miao-Ju; Li, Sin-Jin; Wong, Shiu-Chung; Chiang, Chun-Hsien; Lin, Yuan-Yu; Mersmann, Harry J; Chen, Ching-Yi

doi:10.17632/ydfddjztrj.2

Determination of mitochondrial functions and damage in kidney in female LeeSung minipigs with a high-fat diet-induced obesity

Published: 25 June 2021| Version 2 | DOI: 10.17632/ydfddjztrj.2

Contributors:

Miao-Ju Chien, Sin-Jin Li,

,

, Ching-Yi Chen

Description

We successfully established a DIO-related kidney injury in LeeSung minipigs. In addition, an ATP deficit and oxidative stress were observed in the renal cortex of DIO pigs. Our results provided additional evidences for the involvement of mitochondrial dysfunctions (biogenesis and dynamics) in DIO-related nephropathy.

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National Taiwan University College of Bioresources and Agriculture

Determination of mitochondrial functions and damage in kidney in female LeeSung minipigs with a high-fat diet-induced obesity

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