The Binding Prediction Model of The Iron-responsive Element Binding Protein and Iron-responsive Elements

Published: 28 January 2020| Version 1 | DOI: 10.17632/yfxthhhdtp.1
Contributors:
Kevin Nathanael Ramanto,
Arli Aditya Parikesit

Description

Iron is essential to fulfilling an indispensable role in the biological process in human physiology. Various proteins were known involved in iron metabolism. One of the proteins called iron-responsive element binding protein (IRP) which acts as master iron of cellular iron homeostasis. There are two IRP known to date, which is: IRP1 and IRP2. Previous studies showed IRP bind to iron-responsive elements (IRE) located in 5’-UTR of the transferrin receptor 1. The interaction of IRP/IRE is well studied through many years to find a better treatment for the cellular disorder in iron metabolism. However, the structural differences of both IRP and the binding prediction model of IRP/IRE remain unclear. This dataset provides structure predictions of IRP/IRE by using reliable bioinformatics tools .

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Categories

Protein-RNA Interaction, Computational Bioinformatics, Molecular Docking, Protein Structure Prediction

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