Dermoscopy Characteristics in Amelanotic Melanoma: A Systematic Review and Prevalence Meta-analysis
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Supplementary material for the following article: Dermoscopy Characteristics in Amelanotic Melanoma: A Systematic Review and Prevalence Meta-analysis
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A systematic review and proportional meta-analysis was performed to provide valuable data on the amelanotic melanoma (AM) dermoscopic features. This study followed the MOOSE guidelines and was registered in PROSPERO (CRD42024537621). The eligible studies were observational and case series enrolling patients with AM that displayed dermatoscopic patterns. The statistical analysis was performed using R statistical software version 4.3.2 (R Foundation for Statistical Computing). The following packages were used: “metaprop”, “metafor”, “dmetar”, “ggplot2” and “meta”. Logit-transformation of data was used when the individual study proportion was <0.2 or >0.8. In studies with zero events, we used the doubled-arcsine transformation. The outcomes were evaluated using proportions with 95% confidence intervals (CI). According to Cochrane's recommendations, a random-effects model was used for all outcomes, accounting for variability between studies. The Cochrane Q test and I² statistics were performed to quantify heterogeneity. Endpoints were considered to have low heterogeneity if p-value> 0.10 and I² <25%. To minimize heterogeneity and detect outliers, sensitivity analysis using "leave-one-out" was conducted.