Immunostimulatory cancer-associated fibroblast subpopulations can predict immunotherapy response in head and neck cancer
Published: 15 December 2021| Version 1 | DOI: 10.17632/yk8wj7xgdg.1
Contributors:
Aleksandar Obradovic, Diana Graves, Michael Korrer, Yu Wang, Yaomin Xu, Adam Luginbuhl, Joseph Curry, Sohini Roy, Michael Gibson, Paula Hurley, Charles Drake, Andrea Califano, Young KimDescription
RNA-Sequencing Data Associated with the manuscript "Immunostimulatory cancer-associated fibroblast subpopulations can predict immunotherapy response in head and neck cancer." Includes integrated single-cell RNA-Sequencing data & VIPER inferred protein activity matrix uploaded as Seurat Objects with patient and cluster metadata included, as well as sub-clustered fibroblast Seurat object and spatial geomx data. Also includes bulk RNA-Sequencing datasets of responders vs non-responders to treatment and bulk RNA-Sequencing datasets of sorted fibroblast populations used for cluster phenotyping and ex vivo co-culture experiments.
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Institutions
Columbia University, Vanderbilt University
Categories
Oncology, Cancer Immunotherapy, Head and Neck Cancer, Single-Cell RNA Sequencing