Immunostimulatory cancer-associated fibroblast subpopulations can predict immunotherapy response in head and neck cancer

Published: 15 December 2021| Version 1 | DOI: 10.17632/yk8wj7xgdg.1
Contributors:
Aleksandar Obradovic,
Diana Graves,
Michael Korrer,
Yu Wang,
Yaomin Xu,
Adam Luginbuhl,
Joseph M. Curry,
Sohini Roy,
Michael Gibson,
Paula Hurley,
Charles Drake,
Andrea Califano,
Young Kim

Description

RNA-Sequencing Data Associated with the manuscript "Immunostimulatory cancer-associated fibroblast subpopulations can predict immunotherapy response in head and neck cancer." Includes integrated single-cell RNA-Sequencing data & VIPER inferred protein activity matrix uploaded as Seurat Objects with patient and cluster metadata included, as well as sub-clustered fibroblast Seurat object and spatial geomx data. Also includes bulk RNA-Sequencing datasets of responders vs non-responders to treatment and bulk RNA-Sequencing datasets of sorted fibroblast populations used for cluster phenotyping and ex vivo co-culture experiments.

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Institutions

Columbia University, Vanderbilt University

Categories

Oncology, Cancer Immunotherapy, Head and Neck Cancer, Single-Cell RNA Sequencing

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