A descending cortical–brainstem pathway links emotional state to pain sensitivity

Description

This dataset provides the underlying numerical data supporting the findings of a study investigating a descending medial prefrontal cortex (mPFC)–parabrachial nucleus (PBN) circuit involved in pain–anxiety interactions. The dataset contains the raw numerical values used to generate the quantitative graphs presented in the manuscript, including anatomical quantification, molecular characterization, electrophysiological analysis, single-cell calcium imaging analysis, circuit manipulation experiments, and behavioral assessments in mouse models. These data support the statistical analyses and visualization of the reported findings, and are shared to promote transparency, reproducibility, and further investigation of neural circuit mechanisms underlying emotional modulation of pain.

Institutions

• Beijing Normal University

  Beijing, Beijing
• Guangdong Institute of Intelligence Science and Technology

  Guangdong, Zhuhai

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