Preclinical evaluation of a precision medicine approach to DNA vaccination in Type 1 diabetes

Published: 24 February 2022| Version 1 | DOI: 10.17632/zbksm23r8k.1
Contributors:
Jorge Postigo-Fernandez, Rebuma Firdessa-Fite, Remi Creusot

Description

The figures refer to the PNAS paper of the same title. Blood glucose monitoring (Figures 1, 2, 3): Excel file compiling the incidence of diabetes in each group (Fig.1-2) and percentage of proliferated cells in each mouse (Fig.3). Flow cytometry (Figures 4,5): Raw FCS files with explanatory Excel file for file naming and panels Histopathology (Figure 6): Excel file compiling the scoring from two independent investigators, one blinded to the groups, averages per section, per mouse and per group. There are two tissue sections per slide, 3 slides per mouse (total 6 sections per mouse), and 5 mice per group. Image files are ~1Gb each and cannot be uploaded due to capacity limits.

Files

Steps to reproduce

All methods are provided in the PNAS paper of the same title.

Institutions

  • Columbia University

Categories

Flow Cytometry, Histopathology, Autoimmune Diabetes

Licence