2023 Megan Sheridan Western Blots
Description
Opportunistic anaerobic pathogen Porphyromonas gingivalis (P.gingivalis) has been associated with poor clinical outcomes in patients with oral squamous cell carcinomas (OSCC). However, precise roles and mechanisms by which P.gingivalis infection enhances OSCC growth/proliferation or resistance to cell death remain elusive. Here, we determined that P.gingivalis infection mediates therapeutic resistance via inhibiting lethal mitophagy in OSCC cells and orthotopic tumors.
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Steps to reproduce
UMSCC1A cells were infected with P. gingivalis (100 MOI) for 6 hours followed by treatment with vehicle or LCL768 (30 uM, 2 hours).
Institutions
Categories
Funding
National Institutes of Health
AG069769, CA214461, CA214461-S1, DE016572, DE016572-S1, and P01 CA203628
National Institute of Dental and Craniofacial Research
R01DE030313
National Institute of Dental and Craniofacial Research
T32DE017551