Dataset: Factors Associated with Immediate and Early Non-Invasive Ventilation Failure in Patients with Hypercapnic Respiratory Failure in the Emergency Department

Description

This dataset contains clinical, demographic, vital sign, and laboratory records of 118 adult patients presenting to the emergency department with acute hypercapnic chronic obstructive pulmonary disease (COPD) exacerbations who underwent non-invasive ventilation (NIV). The data includes variables related to baseline and post-NIV arterial blood gases, mask fit assessments, ventilatory settings, and clinical outcomes (NIV success vs. failure) used for multivariable logistic regression and ROC analyses.

Steps to reproduce

1. Data Collection and Patient Selection: Apply strict inclusion criteria (baseline pH < 7.35, PaCO₂ > 45 mmHg) and exclusion criteria (severe hemodynamic instability, facial deformities preventing basic mask seal, refusal of NIV, overt gastrointestinal bleeding, upper airway obstruction, acute ischemic heart disease, or need for immediate intubation prior to NIV). Exclude cases with missing baseline clinical or arterial blood gas (ABG) data to derive the final complete-case analytical cohort. 2. Data Preparation and Coding: Record demographic information, baseline vital signs, and initial ABG parameters. Code categorical and interface-related variables, specifically the presence of objective physical anatomical barriers (e.g., a facial beard or mustache). Document ventilator settings, including initial and adjusted EPAP and IPAP values. (Note: Subjective clinician-assessed 'mask fit' evaluations were explicitly excluded from the analytical framework to prevent unblinded observer bias). 3. Definition of the Dual-Outcome Framework: Classify the treatment trajectory using a strictly defined dual-outcome framework confined to the initial 1-hour emergency department resuscitation phase: Primary Clinical Outcome: Requirement for prompt endotracheal intubation or the occurrence of cardiac arrest. Secondary Composite Outcome (Immediate Unfavorable Physiological Response): Persistent severe acidemia (pH < 7.25), severe hypercapnia (PaCO₂ ≥ 75 mmHg), intubation, or cardiac arrest.

Institutions

• Akdeniz University

  Antalya, Antalya

Categories

Licence