Ex vivo therapeutic base and prime editing using chemically derived hepatic progenitors in a mouse model of tyrosinemia type 1. Kim et al.
Polyploid characteristics of HT1-mCdHs. (A) The ploidy distribution of HT1-mCdHs was determined using Hoechst 33342 fluorescence and FACS analysis. (B) Isolated 2c HT1-mCdHs were expanded in reprogramming medium for 14 days. The ploidy distribution of these cells shifted to 4c (3.69%) and 8c (15%) over this time period.