Longitudinal changes in a blood-based prognostic liver secretome signature and long-term hepatocellular carcinoma risk in cirrhosis

Name: Longitudinal changes in a blood-based prognostic liver secretome signature and long-term hepatocellular carcinoma risk in cirrhosis
Creator: Hiroyuki Suzuki
Published: 2026-06-15T19:44:13.688Z
Keywords: Cirrhosis, Hepatocellular Carcinoma, Liver Disease, Risk Stratification

Suzuki, Hiroyuki; Lopez, Camden; Katz, Courtney; Kanzaki, Hiroaki; Fujiwara, Naoto; Dinc, Janet; Page-Lester, Stephanie; Dahlgren, Jackie; Selvakumar, Pratibha; Raman, Indu; Raj, Prithvi; Parikh, Neehar; Roberts, Lewis; Feng, Ziding; Reddy, K.; Marrero, Jorge; Singal, Amit; Hoshida, Yujin

doi:10.17632/zyz3xxczkh.1

Longitudinal changes in a blood-based prognostic liver secretome signature and long-term hepatocellular carcinoma risk in cirrhosis

Published: 15 June 2026| Version 1 | DOI: 10.17632/zyz3xxczkh.1

Contributors:

, Camden Lopez, Courtney Katz, Hiroaki Kanzaki, Naoto Fujiwara, Janet Dinc, Stephanie Page-Lester, Jackie Dahlgren, Pratibha Selvakumar, Indu Raman, Prithvi Raj, Neehar Parikh, Lewis Roberts, Ziding Feng, K. Reddy, Jorge Marrero, Amit Singal, Yujin Hoshida

Description

This is a nested case-control study based on the National Cancer Institute (NCI) Early Detection Research Network (EDRN) HCC Early Detection Strategy (HEDS) cohort, a prospective multi-center cohort of cirrhosis patients for phase III validation of HCC biomarkers under the prospective specimen collection, retrospective blinded evaluation (PRoBE) design.The cases are cirrhosis patients who had serum samples at 1 and/or 2 years form the enrollment (with 3-month window). The 8 protien PLSec assay was performed in a blinded fashion at University of Texas Southwestern BioCenter using frozen serum samples archived in the HEDS biorepository.

Longitudinal changes in a blood-based prognostic liver secretome signature and long-term hepatocellular carcinoma risk in cirrhosis

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