This database is the original data demonstrating the decrease of ECP expression of eosinophils in the cell model and an allergic animal model after simvastatin treatment was not due to inhibition of ECP formation or its release but the decrease of cell counts. Simvastatin induced G1/S cell cycle arrest and the associated cyclin A to inhibit subsequent HC15 cell proliferation via the mevalonate pathway.
exp. 1 data correspond to figure 1, exp. data 2 correspond to figure 2, exp. 3 data correspond to figure 3, and exp. 4 data correspond to figure 4. Please note that exp. 2 data files contain several datasheets and each datasheet corresponds to each animal.