Atherosclerosis

Total mRNA sequencing of in vitro polarised, human monocyte-derived macrophage phenotypes. Polarised with IFNγ+LPS, IL–4, IL–10, oxPAPC and CXCL4, compared to unpolarised control. Averaged from separate sequencing of 8 healthy human donors.

Original data used for QTL analysis

Western Blot results in this study.

Lipoprotein(a) [Lp(a)] is an important independent cardiovascular risk factor. However, Lp(a) levels are lower in patients with chronic liver disease than in healthy subjects. Furthermore, Lp(a) levels decrease as residual liver function declines. Although non-alcoholic fatty liver disease (NAFLD), especially advanced non-alcoholic steatohepatitis (NASH), increases the risk of cardiovascular diseases, the relationship between serum Lp(a) level and NASH is unknown. Thus, we examined the relationship between serum Lp(a) levels and NAFLD and clarified the significance of Lp(a) measurements for cardiovascular disease screening in patients with NAFLD.

Data from the publication 'Sex-specific differences in cytokine signaling pathways in circulating monocytes of cardiovascular disease patients' https://doi.org/10.1016/j.atherosclerosis.2023.04.005 We generated sex-biased gene expression signatures by comparing male versus female monocytes of coronary artery disease (CAD) patients (n = 450) from the Center for Translational Molecular Medicine-Circulating Cells Cohort. the data includes 3 dataframes : clin_cvd: patient info geneexprs_hgnc: gene expression after batch correction GES_cvdmf_HGNC: limma results (male vs female)

Added anonymized human patient data