Toxicology Letters

Raw data

These files are the statistic results of table 1 and table S2 with SPSS software.

The optimal measuring timing of Cystatin C (CysC) for early detection of contrast-induced acute kidney injury (CIAKI) remains un-studied. We conducted this systematic review and meta-analysis study to elucidate further on this issue. We searched PubMed, MEDLINE, and Embase from inception until March 2018 for studies evaluating the diagnostic accuracy of CysC for predicting CIAKI in patients exposed to contrast agents during diagnostic examinations or cardiac/peripheral catheterizations. A total of 10 relevant studies, comprising 2554 patients, were included. The included studies were divided into two groups: <24-hour and 24-hour groups, based on CysC measuring timing (i.e., hours after contrast agent exposure). Compared with creatinine, the pooled diagnostic odds ratio of CysC for detecting CIAKI of the <24-hour and 24-hour groups was 7.59 and 53.81, respectively. The pooled sensitivity of the <24-hour and 24-hour groups was 0.81 and 0.88, respectively. The pooled specificity of the <24-hour and 24-hour groups was 0.64 and 0.88, respectively. The area under the hierarchical summary receiver operating characteristic curve of the <24-hour and 24-hour groups was 0.75 and 0.93, respectively. Collectively, these data indicate that 24 hours after contrast agent exposure is the optimal measuring timing of CysC for early detection of CIAKI.

Research data.

IMPORTANT : PLEASE DISREGARD VERSION 1 OF THIS UPLOAD SINCE IT INCLUDES ERRONEOUS INFORMATION. This excel file (DOI: 10.5281/zenodo.3433224) provides physiological parameters and their inter-individual variability (mean, coefficient of variation, sample size) for three farm animal species: cattle (Bos taurus), sheep (Ovis aries), and swine (Sus scrofa domesticus). These physiological parameters were estimated based on the results of extensive literature searches and specific experimental data described in Lautz et al., (2020). This file is associated with R codes (DOI: 10.5281/zenodo.3432796) for generic PBK models, partition coefficient Quantitative Structure Activity Relationship (QSAR) models for each farm animal species and parameterisation of the model. The full data collection and implementation of the models using case studies are described in Lautz et al., 2020 (10.1016/j.toxlet.2019.10.008).

Disposition of TBBPA-BDBPE following ex vivo application to rat or human skin, in vivo application to rat skin and estimated human in vivo from the ex vivo rat and human and in vivo rat data

The data used in this manuscript came from published literature.

Employing acrolein, a potent airway irritant, and TCE, with low irritancy, authors hypothesized that airway injury and inflammation would be involved in eliciting neuroendocrine-mediated systemic alterations. Male and female Wistar-Kyoto rats were exposed nose-only to air, acrolein or trichloroethylene (TCE) in incremental concentrations over 30 min, followed by 3.5-hr exposure to the highest concentration (acrolein - 0.0, 0.1, 0.316, 1, 3.16 ppm; TCE - 0.0, 3.16, 10, 31.6, 100 ppm) while performing head-out plethysmography (HOP), and animals were necropsied immediately post-exposure to assess nasal and lung injury/inflammation, systemic neurohormones, circulating stress hormones and also metabolic hormones.